MEDELLÍN, ANTIOQUIA, COLOMBIA

Sapito Medicine is extracted from a toad called Bufo Alvarius, which inhabits the Sonora desert, northern Mexico. A toxin containing the organic active substance 5-MEO-DMT is extracted from its glands, which is also present in various genera of plants of European and Asian origin, such as Yopo.
The toad does not suffer any damage during extraction. Organic 5-MEO-DMT is a neurotransmitter that is also found in the human brain naturally. The human body secretes it through the pineal gland; in small amounts during positive moods, such as joy and euphoria; in greater quantities during deep sleep, at the time of birth and at the time of death.
In 1965, a team of researchers from Germany announced through the journal Nature that they had been able to isolate 5-MEO-DMT from human blood. Subsequent research has classified the 5 MEO DMT as “the first human endogenous psychedelic”, since it is not only found in nature, but is also produced by our own body.
It has been scientifically demonstrated that, like other tryptamines, 5 MEO DMT promotes the reabsorption of serotonin and melatonin, causing changes in the perceptual sphere.
Also known as “brain food”, since the brain processes it in a similar way to glucose. When consuming 5-MEO-DMT, the body increases the production of neurotransmitters such as serotonin, melatonin, (tryptamine) and enzymes that favor the healing and regeneration of the body. This causes the release of a considerable amount of stress (unconsciously accumulated), thus unblocking the immune system and causing the physical, mental and/or emotional conditions to be self-corrected and gradually healed.
The crystalline substance is burned and synthesized in smoke and then smoked. The smoke must be retained inside the body for a few seconds, being an organic compound existing in our body it is absorbed naturally.
The climax of Sapito’s medicine is 5 to 15 min. All processes are different, depending on the person and how their body reacts. Medicine continues to work for days and gradually decreases; in some cases even for later months.
Here they play an important role: the awareness of the person, the will, the influence of the environment, the habits of the person (food, vices, thoughts, emotions, etc.). That is, these factors can change our progress on the path of Sapito medicine and our internal healing, if we allow it. Or, they can help us increase our improvement, our healing, our internal work; if we decide to take advantage of them and use them for our benefit.
The changes in the person’s life will be gradual. In some cases of magnified ego, the person does not notice the changes, but the people who are part of their environment do. All changes secondary to the intake of Sapito medicine are positive and help improve the patient’s ways of behavior.
Depending on the state of consciousness or intoxication, the participant may experience some of the following experiences /sensations during the ceremony.
Massive release of accumulated stress (conscious or unconscious). Liberation of repressed emotions or feelings throughout our lives.
Dissolution of unconscious cellular memories that cause addictions, compulsions, psychosomatic diseases, manias and sufrimientos.
Partial or total disconnection from physical and/or visual reality (since it modifies our perception).
Sensation that the body explodes in millions of particles. Fusion of the patient with the environment that surrounds him (being here and now). Restructuring of synapse networks in our brain.
After having ingested the organic 5-MEO-DMT, the participant experiences sensations of a deep release of their emotional traumatic loads and release of accumulated stress, these effects will continue for several hours or even for several days later.
Profound spiritual experiences
Feelings of oneness, unity with the universe or divine
Ego dissolution or transcendence of self
Deep emotional release
Letting go of trauma, grief, fear, or suppressed emotions
Cathartic experiences that lead to emotional clarity
Mental clarity and insight
Gaining new perspectives on life, relationships, or purpose
Breaking old patterns or limiting beliefs
Healing and therapeutic benefits
Reduction in symptoms of depression, anxiety, PTSD (anecdotally reported)
Sense of inner peace or contentment post-ceremony
Increased presence and awareness
Heightened mindfulness and appreciation for the present moment
Reconnection with the body and breath
Expanded consciousness
Accessing non-ordinary states of awareness
Experiences of timelessness or infinity
Potential for personal transformation
Strong motivation to make life changes
Improved sense of alignment with one’s values or truth
The medicine is inhaled through vaporized secretion, leading to an immediate and intense experience of expanded consciousness. Participants are guided in a safe, ceremonial setting with experienced facilitators to support their journey.
No. While both contain DMT, Bufo (5-MeO-DMT) is significantly more potent and fast-acting than Ayahuasca or synthetic DMT. The experience is often described as complete immersion into pure awareness rather than a visionary journey.
Bufo induces deep relaxation, altered perception, and a sense of surrender. Some people experience mild physical sensations, but the focus remains on the inner journey.
It is recommended to engage in meditation, breathwork, and intention-setting. Avoiding alcohol, heavy foods, and unnecessary stressors can help cultivate the most receptive state for healing.
When used in a ceremonial setting with trained facilitators, Bufo is considered safe. However, it is not recommended for individuals with heart conditions, severe mental health disorders, or those on certain medications.






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